More specifically, the genetic landscape [e.g., PTEN loss, c-Myc amplifications [11]] and signaling pathways [e.g., the T-cell receptor [5, 59]] characteristic of GATA-3 driven T-cell lymphomas are associated with significant translational output and hyperactive RiBi [58, 60]. Here, PTEN is linked to T-cell non-Hodgkin lymphoma.