Like CDK4 and CDK6, Aurora kinases (AURKA, AURKB, and AURKC) play crucial roles in cell cycle regulation and progression to mitosis.282 In NSCLC, AURKA expression was found to be a poor prognostic factor, and Aurora kinase signaling upregulation has been implicated in KRAS-mutant malignancies, namely, mutant KRAS NSCLC, and in sotorasib-resistant cell lines.283,284 In these cell lines, the knockdown of AURKA or AURKA/AURKB inhibition resulted in antitumor activity. This evidence concerns the gene KRAS and non-small cell lung carcinoma.