Nine months later, a lesion progressed due to immune evasion mediated by the loss of the chromosome 6 haplotype encoding HLA-C*08:02 MHC 1, which is required for recognition by KRAS G12D-reactive T cells.367 Regression of widespread metastatic foci in a patient with advanced pancreatic cancer was also noted with treatment using HLA-C*08:02-restricted autologous T cells.368. Here, HLA-C is linked to familial pancreatic carcinoma.