For example, molecules that disrupt the CXCR1/2-MDSC axis may be combined with ICIs and KRAS/or SHP2 inhibitors to reverse MDSC-mediated immunosuppression.301,302 Other combinations of SHP2, KRAS, and IC inhibitors may also reshape the TME and suppress the adaptive signaling of cancer cells, which diminishes sensitivity to KRASG12C inhibition.207,303,304. Here, PTPN11 is linked to cancer.