CD274 and neoplasm: They are also associated with genomic instability, a high tumor mutational burden, and a better response to PD-L1 inhibitors due to increased expression of PD-L1 receptors and shorter OS in patients treated with platinum-based adjuvant chemotherapy.136KRAS mutations control the intrinsic features of tumors, such as proliferation and survival, as well as the extrinsic environment that allows them to spread by promoting immune escape.