XPO1 and neoplasm: The nuclear export protein exportin 1 (XPO1) acts downstream and at the convergence of many cancer signaling pathways.257 As a nuclear exporter, it plays a vital role in maintaining cellular homeostasis by controlling the export of protein cargos from the nucleus to the cytosol.257 In cancer, the export of tumor suppressor genes from the nucleus prevents them from performing their normal function in regulating cell growth258; hence, increased XPO1 expression has been correlated with poor prognosis across several solid and hematologic malignancies.