CD8A and neoplasm: As described in several previous studies, CXCL13 expression distinguishes CD8+ T cells with tumor reactivity and reflects characteristics of exhaustion.22,23 We next assessed the tumor-reactive scores for each CD8+ T-cell subpopulation and verified that CXCL13+CD8+ T cells had the highest score (Fig. 3h; Supplementary Fig. 5d).