A meta-analysis of 17 CKD studies showed sKlotho is positively correlated with calcium (r = 0.14, I2 = 66%, p < 0.05), negatively correlated with serum phosphate (r = −0.21, I2 = 84%, p < 0.05), and inversely related to PTH levels (r = −0.23, I2 = 40%, p < 0.05) [167]. Here, PTH is linked to chronic kidney disease.