Furthermore, the ADAR1 p150 overexpression model was utilized to validate the proposed mechanism.<h4>Results</h4>ADAR1 expression was significantly elevated in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tissues compared with adjacent non-tumor tissues (LUAD: P=3.70×10-15, LUSC: P=0.016). The gene discussed is ADAR; the disease is squamous cell lung carcinoma.