CHKB and muscular dystrophy: This contrasts the Chkb−/− mouse model of CHKB mediated rostrocaudal muscular dystrophy where (1) unaffected muscle displayed an increase in expression of CHKA and was spared from disease (21, 50, 51, 70, 71) and (2) ectopic expression of CHKA in Chkb−/− mouse muscle was sufficient to restore normal muscle structure and function (72).