Previous studies have demonstrated that LGALS3BP, secreted by neuroblastoma cells, binds to galectin‐3 on bone marrow mesenchymal stem cells and activates the Ras/MEK/ERK signaling pathway, up‐regulates three C/EBP‐binding sites on the IL‐6 promoter, ultimately enhancing IL‐6 transcription and secretion [27]. This evidence concerns the gene MAP2K7 and neuroblastoma.