IGFBP2 and idiopathic pulmonary arterial hypertension: Notably, our analysis detected significant up‐regulation of several established IPAH‐associated proteins among the DEPs, such as vWF (FC = 2.05, p < 0.001), ICAM1 (FC = 1.25, p < 0.001), IGFBP2 (FC = 1.69, p < 0.001), and fibronectin 1 (FC = 1.68, p < 0.001) [11, 12, 13, 20], which is consistent with previous reports that collectively corroborate the involvement of extracellular matrix remodeling and inflammatory pathways in IPAH pathogenesis.