LAT2 and allergic disease: We noted that SLC7A5 (LAT1), SLC7A8 (LAT2), and SLC3A2 (CD98), part of LAT1 and LAT2 heterodimer complexes, were significantly downregulated in allergic asthma but not in allergic rhinitis (Figures 7D, 7E, and S18D), suggesting decreased transport of Phe into the Th2 cells in more advanced allergic disease.