Building on earlier reports that associated SENP3 with oxidative stress and vascular remodeling [17, 18], we now demonstrate that SENP3 accumulates in human and mouse atherosclerotic lesions and is critically required for PDGF-BB-induced downregulation of contractile markers and acquisition of migratory and proliferative capacities. Here, SENP3 is linked to Atherosclerotic lesion.