IGHE and Alzheimer disease: Patient studies have shown elevated serum GAL9 levels, increased frequencies of TIM3+ CD4 T cells, and positive correlations with clinical severity indices (SCORAD/EASI), IgE and eosinophils; moreover, GAL9 engagement limits Th1/Th17 proliferation/survival while promoting Th2/Th22 polarization, which is characteristic of AD [31].