In this study we aimed to investigate the expression of a selection of miRNAs with known involvement in pulmonary pathologies in the trauma setting, in a porcine polytrauma model comparing two surgical treatment methods (i.e., ETC and DCO), as well as one separate ETC treatment group receiving C5/CD14 inhibition (drug-based treatment). Here, CD14 is linked to Leri-Weill dyschondrosteosis.