APP and Alzheimer disease: Using a transgenic mouse model that overexpresses human amyloid precursor protein (APP) with two mutations linked to familial AD (the Swedish and Indiana mutations, the APPJ20 strain),16 it has already been demonstrated that EC synaptic function and dendritic spine morphology are affected prior to any detectable plaque accumulation, driving an impairment of episodic‐like memory retrieval evaluated using the object‐place‐context recognition task (OPCRT).