NOTCH1 and colorectal cancer: Existing research has revealed distinct roles of NOTCH1 in different malignancies: in breast cancer, NOTCH1 activation can counteract mitotic catastrophe induced by BRCA1 deficiency via restoring S/G2 and G2/M cell cycle checkpoints, thereby accelerating the malignant progression of triple-negative breast cancer (25); in colorectal cancer, inhibition of NOTCH1 expression can significantly attenuate cancer cell proliferative capacity and enhance their radiosensitivity (26).