ARHGEF37, a member of the Rho guanine nucleotide exchange factor family, can increase the Cdc42-GTP level in HCC cells, and enhanced the extravasation and lung metastatic capability of HCC cells through promoting the formation of invadopodia, consequently resulting in disruption of the interaction between endothelial cells and pericytes (24) and also identified as key biomarkers for fibromyalgia, which is implicated in critical processes such as ion homeostasis, cell signaling, and neurobiological functions (25). This evidence concerns the gene ARHGEF28 and fibromyalgia.