In addition, DYRK1A knockdown directly in the hippocampus in Aβ-overexpressing 5xFAD mice significantly attenuated cognitive impairment and neuroinflammatory responses, increased anti-oxidative/anti-inflammatory HO-1 levels, and reduced Aβ pathology by suppressing BACE-1 activity. This evidence concerns the gene BACE1 and Cognitive impairment.