Moreover, DYRK1A knockdown significantly diminished the mRNA expression of markers for AD-related microglial dynamics (IBA-1, ITGAX, and TREM2) and RA–disease-associated microglia (DAM) interactions (CR3 and C1QA) but not CLEC7A (Figures 3F-H). The gene discussed is TREM2; the disease is Alzheimer disease.