CRIPTO3 and Alzheimer disease: Moreover, AAV-DYRK1A shRNA injection significantly diminished the mRNA levels of the AD-related microglial markers IBA-1, ITGAX, and CLEC7A and the RA–DAM interaction markers CR3 and C1QA in aged 5xFAD mice compared to AAV-control shRNA injection, whereas TREM2 mRNA expression was not altered (Figures 4H–J).