APP and Mental deterioration: Previous studies reported that soluble oligomers of Aβ, which is formed by the sequential proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases (3), are responsible for the disruptions of synaptic communication, the induction of glial hyperactivation, and the subsequent neuroinflammation that ultimately lead to neuronal degeneration and cognitive decline (4).