PPI networks constructed between DE genes and previously identified type 1 diabetes drug–gene targets (IL2RA, IL2RB, IL6ST, IL6R, TYK2, IFNAR2, IL12B, IL23A, IL2RG, JAK1, JAK2, and JAK3) (13)—which have been targeted in clinical trials for autoimmune-mediated diseases—demonstrated extensive connectivity among these genes (Figure 3). The gene discussed is JAK3; the disease is type 1 diabetes mellitus.