Cholesterol participates in the composition of biological membranes, maintaining the fluidity of lipid bilayers, forming lipid rafts, and solubilizing other lipids to coordinate the activation of many signal transduction pathways Altered cholesterol metabolism facilitates the proliferation of tumor cells and induces the apoptosis of tumor cells by regulating the oncogenic pathway PI3K/AKT/mTOR, and it induces CD8+ T cell exhaustion to create an immunosuppressive TME (52–54). This evidence concerns the gene CD8A and neoplasm.