Immunohistochemical analysis of the ovarian cancer marker HE4 and the proliferation marker Ki67 further demonstrated that both exoctrl and exotLyP-1 inhibit ovarian cancer cell proliferation, with the inhibitory effect of exotLyP-1 being more pronounced (Figures 4L, M; Supplementary S2E, F). The gene discussed is WFDC2; the disease is ovarian cancer.