While the WGI/Y motif is associated with CD1 recognition, LGD containing public CDR3 sequence TRDV1-TRDD3-CALGELGD was previously shown to be expanded in CMV-infection and assumed to belong to the “adaptate” γδ-T-cell compartment, representing a radically new adaptive immunobiology (92) which displays potent cytolytic function against virally infected and malignant cells, strong cytokine production and expression of NKRs (93–95). Here, CD1C is linked to cytomegalovirus infection.