CD1A and cytomegalovirus infection: While the WGI/Y motif is associated with CD1 recognition, LGD containing public CDR3 sequence TRDV1-TRDD3-CALGELGD was previously shown to be expanded in CMV-infection and assumed to belong to the “adaptate” γδ-T-cell compartment, representing a radically new adaptive immunobiology (92) which displays potent cytolytic function against virally infected and malignant cells, strong cytokine production and expression of NKRs (93–95).