Significantly, the ZMYM2 heterozygous mutant mouse model also exhibits metabolic abnormalities, including chronic mild hyperglycemia (progressively elevated blood glucose levels until 90 days of age), significantly reduced fasting serum insulin, and impaired insulin secretion capacity (Clissold et al., 2015; Pu et al., 2025). The gene discussed is ZMYM2; the disease is Hyperglycemia.