While typically difficult to detect in normal tissues, SUZ12 has been found to be amplified and overexpressed in various human cancers, such as ovarian cancer, mantle cell lymphoma, breast cancer, head and neck squamous cell carcinoma (HNSCC), colorectal cancer, and non-small cell lung cancer (Li et al., 2012; Iliopoulos et al., 2010; Martín-Pérez et al., 2010). Here, SUZ12 is linked to head and neck squamous cell carcinoma.