In CAKUT patients carrying heterozygous nonsense or frameshift mutations in ZMYM2, various neurological manifestations have been observed, including microcephaly, developmental delay, intellectual disability, speech delay, and infantile hypotonia (Connaughton et al., 2020; Jourdeuil et al., 2025). The gene discussed is ZMYM2; the disease is congenital anomaly of kidney and urinary tract.