In Npc1−/− mice, RNA sequencing revealed disrupted myelin gene expression and aberrant activation of neuronal programs in oligodendrocyte lineage cells, along with reduced numbers of OLIG2+ and MBP+ cells, increased apoptosis, and a loss of H3K27me3 and H3K9me3 marks (Kunkel et al., 2023), further uncovering pathogenic mechanisms in NPC. The gene discussed is NPC1; the disease is nasopharyngeal carcinoma.