Furthermore, APS combined with chemoradiotherapy further reduced tumor marker levels, including: CEA (MD = −1.24, 95% CI: −1.58 to −0.89), SCC (MD = −1.18, 95% CI: -1.51 to −0.84), and CA125 (MD = −9.12, 95% CI: −18.22 to −0.01). This evidence concerns the gene CEACAM5 and neoplasm.