Based on the established role of IF1 in promoting HCC progression through mechanisms like EMT and angiogenesis [15,16], and considering the critical contribution of EMT to VM formation [7], we hypothesized that IF1 might also play a important role in VM within HCC, as suggested by GeneCard and The Cancer Genome Atlas (TCGA) databases. This evidence concerns the gene ATP5IF1 and hepatocellular carcinoma.