Molecular docking confirmed stable binding between Bisphenol A and COL1A1, COL1A2, and IGF1, while molecular dynamics simulations highlighted the particularly favorable binding affinity between COL1A1 and Bisphenol A. This suggests that Bisphenol A may directly interact with the protein products of these three genes to induce the onset and progression of MASLD, with COL1A1 playing a critical role. Here, COL1A1 is linked to metabolic dysfunction-associated steatotic liver disease.