Further analysis through PPI network and machine learning identified key targets MMP9, COL1A1, COL1A2, IGF1, DPP4, and CXCR2 were identified as critically involved in the pathogenesis of MASLD, with COL1A1, COL1A2, and IGF1 identified as core targets. The gene discussed is IGF1; the disease is metabolic dysfunction-associated steatotic liver disease.