Disruption of K+ buffering through astrocytic Kir4.1 dysfunction in spinal cord injury (Olsen et al., 2010; Benson et al., 2023; Barbay et al., 2025), is likely to elevate [K+]o, paralleling findings from epilepsy studies (Djukic et al., 2007; Tong et al., 2014). This evidence concerns the gene KCNJ10 and epilepsy.