TIMER2.0 analysis showed that overexpression of PRDX1 was negatively correlated with infiltration of CD4+ and CD8+ T cells, while positively correlated with infiltration of M2 macrophages in CRC (Figure S1B), suggesting a potential role for PRDX1 in shaping anti‐tumor immunity via macrophage polarization. The gene discussed is CD8A; the disease is colorectal carcinoma.