Reciprocally, PRDX1 ablation in macrophages restrains M2 polarization and enhances T‐cell‐mediated anti‐tumor immunity by promoting the secretion of inflammatory factors (IL‐1β and TNFα) via activation of JAK‐STAT1/NF‐κB signaling pathways. The gene discussed is NFKB1; the disease is neoplasm.