To investigate whether PRDX1 deficiency in macrophages inhibits CRC growth by enhancing T‐cell‐mediated cytotoxicity, we mixed MC38 cells with BMDMsPRDX1‐KO cells or BMDMsWT cells (3:1 ratio) and injected subcutaneously into C57BL/6J mice pre‐cleared of macrophages by clodronate liposomes. Here, PRDX1 is linked to colorectal carcinoma.