Furthermore, PRDX1 knockdown in CRC cells inhibited M2 macrophage polarization by impairing hypoxia‐inducible factor 1α (HIF‐1α)/GLUT‐1‐mediated glycolysis and lactate secretion. Mechanistically, PRDX1 binds to Cullin‐2 as a molecular chaperone, thereby suppressing ubiquitination and degradation of HIF‐1α. The gene discussed is PRDX1; the disease is colorectal carcinoma.