Despite these advances, two critical gaps persist: (i) whether USP30 exhibits functional nuclear localization, a feature observed in other mitochondrial proteins, remains unexplored, and (ii) its functional significance beyond mitochondrial contexts is unknown, particularly in aggressive cancers like triple‐negative breast cancer (TNBC), which lacks targeted therapies and frequently exhibits therapy‐resistant stem cell populations. The gene discussed is USP30; the disease is cancer.