This aligns with broader evidence from other studies where tumor MHC-II expression has been linked to CD4+ and CD8+ T-cell responses, However, it should be noted that these are correlations rather than demonstrated causative effects, and alternative explanations such as cytokine-driven induction (e.g., IFN-γ) of HLA-DR by infiltrating immune cells could also underlie the observed relationships. This evidence concerns the gene CD8A and neoplasm.