SMAD3 and neoplasm: RhoQ inhibition was found to enhance transforming growth factor-β (TGF-β)-Smad3 phosphorylation (41), tumor cells expressing SUR1 promote the transformation of normal fibroblasts into cancer-associated fibroblasts (CAFs) and tumor progression by reducing the delivery of tumor-suppressive let-7a-5p miRNA via exosomes (42), and long non-coding RNA LINC00473-mediated nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation suppression inducing apoptosis (43).