HDAC1 and lung cancer: In lung cancer, SUMOylation contributes centrally to pathogenesis and therapy resistance through multiple mechanisms: Ubc9/PIASy-mediated SUMOylation of Slug promotes NSCLC metastasis by enhancing its transcriptional repression activity through HDAC1 recruitment (100), PIAS1 facilitates SUMO1-SMAD4 complex formation, enhancing vimentin expression and cell migration (101).