Regardless, these antibodies add to a growing arsenal that can help dissect mechanisms of anti-VEGFA evasion, clarify the complex interplay between both growth factors, and support development of effective strategies that prevent pro-angiogenic signals and promote tumor vascular normalization – features that may contribute to design of future multi-functional antibodies that include anti-VEGF/ anti-PlGF components. Here, PGF is linked to neoplasm.