(Hallmark): consumptive; PLT-rich microvascular thrombiTTP: ADAMTS13 deficiency† →↑ UL-VWFM→ widespread PLT activationHUS: Shiga toxin/endothelial damageaHUS: complement dysregulation → endothelial injuryHELLP: Abnormal development of placental vasculature (early in pregnancy) → placental hypoxia/hypoperfusion/ischemia→ anti-angiogenic factors → endothelial dysfunction/activation↑ P-selectin, ↑ circulating platelet–leukocyte aggregates, ↑ procoagulant microparticles(chronic) exposure to UL-VWFM & endothelial injury→ platelet exhaustion. The gene discussed is ADAMTS13; the disease is endothelial dysfunction.