IL22 and Infertility: The connection between BAs and androgens remains unclear; however, a recent translational study suggests that in PCOS, alterations in the gut microbiota and BA profile may play a role in ovarian dysfunction: transplantation of fecal microbiota from women with PCOS into mice altered BA metabolism, disrupted estrous cycles, and caused infertility through a pathway involving interleukin-22 and small intestinal immune cells (18).