Although plasma ACTH levels and their immunohistochemistry were normal or unavailable in a small number of patients with MEN 2, after the resection of MTC and/or PHEO, or with drug control, when their hypercortisolemia is alleviated and no other ectopic tumors are detected, ECS should be considered to originate from MTC and/or PHEO (Table 1). The gene discussed is POMC; the disease is multiple endocrine neoplasia.