APLNR and Hypertension: [34] found that in DOCA/salt-induced hypertension, renal ELA overexpression alleviates hypertension and renal injury by inhibiting the renal NADPH oxidase/ROS/NLRP3 inflammasome pathway, and this effect is not affected by APJ deficiency, indicating that ELA may act via an APJ-independent mechanism in this context.