These findings strongly suggest that IL-1β/IL-1R1 signaling contributes to seizure onset, establishing IL-1β as one of the key mediators of epilepsy-associated neuroinflammation (Radu et al., 2017; Vezzani et al., 2019; Soltani Khaboushan et al., 2022; Yue et al., 2022). Here, IL1R1 is linked to epilepsy.