With respect to BID truncation events, when HCT116 (human colorectal carcinoma) cells are treated with TRAIL in conjunction with erastin (Hou et al., 2023) and artesumate (Jiang et al., 2021), which induce ferroptosis, TRAIL classically enhances caspase-8 activation, and BID truncation increases in parallel. This evidence concerns the gene BID and colorectal carcinoma.