RHOA and pulmonary arterial hypertension: ARHGEF12, also known as leukemia-associated Rho GEF (LARG), has been implicated in the progression of various diseases, including cancer, pulmonary arterial hypertension, and pathogenic thrombus formation, primarily through its role in RhoA activation and its effects on the actin cytoskeleton (Ghanem et al., 2022).