Pocket CIED infection: male sex, young age, CRT systems, CIED reoperations, systemic lupus erythematosus, previous valvular surgery, and recent use of dicloxacillin.Systemic CIED infection: male sex, young age, CRT systems, severe renal insufficiency/dialysis, prior valvular surgery, dermatitis and usage of insulin. This evidence concerns the gene INS and Renal insufficiency.