The shared locus located on chromosomal region 20q13.13 (lead SNP rs2295714) had discordant effect directions with MDD and IL-6, and implicated the gene staufen1 (STAU1), which specifically regulates several genes involved in inflammatory and immune response regulation (Diaz-Muñoz et al., 2015). This evidence concerns the gene STAU1 and major depressive disorder.