CYP27B1 and Hypercalcemia: Approximately 10% of sarcoidosis cases are associated with hypercalcemia via increased CYP27B1 [6]. Inactive form of vitamin D3 synthesized in the skin is metabolized in the liver to 25(OH)D3, which is then hydroxylated by CYP27B1 to the active form of 1,25(OH)2D3. It has been believed that increased extrarenal CYP27B1 leads to overproduction of 1,25(OH)2D3, causing hypercalcemia in sarcoidosis [7]. In the present case, we showed an increased expression of CYP27B1 in renal sarcoidosis.