The histopathologic subtype of DLBCL in this patient is the non-GCB subtype with MYC/BCL-2 dual expression and a high Ki-67 proliferative index, consistent with a biologically proliferative tumour, which is reflected in the clinical presentation of acute splenomegaly with splenic infarcts. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.