IL17A and gastroesophageal reflux disease: This process is closely linked to poststroke cognitive impairments (e.g., vascular dementia).[18] Although IL-17-associated mechanisms exhibit tissue specificity (GERD primarily involves gastrointestinal inflammation, whereas IS focuses on cerebral microenvironmental dysregulation) their core pathology converges on IL-17-mediated chronic inflammation driven by Th17 cells.