PLAC8 and Sepsis: Among these, FCER1G, S100A12, PIK3AP1, RETN, PROK2, PLSCR1, PLAC8, CD55, and STOM were significantly upregulated in sepsis patients relative to healthy controls, while CFD, HLA-DMB, HLA-DMA, and RPS23 were significantly downregulated (all P < .05; Fig. 4E–G).