IL6 and bile duct papillary neoplasm: Notably, sdLDL-C not only directly promotes IPN formation, but also upregulates IL-6 through activation of the NOD-like receptor thermoprotein structural domain-related protein 3 (NLRP3) inflammasome, forming a positive feedback loop of “lipid deposition-inflammation amplification-vascular neogenesis” (Zhao et al,[1] 2023; Liu et al,[2] 2020).