GJB2 and KID syndrome: Although the pedigree appeared to suggest an autosomal recessive inheritance pattern- due to parental consanguinity and an affected sibling- most reported cases of KID syndrome are caused by autosomal dominant, often de novo, mutations in the GJB2 gene, particularly the D50N variant.[10,11] This discrepancy underscores the importance of molecular confirmation in syndromic ichthyoses and highlights how consanguinity can mask dominant inheritance by mimicking a recessive patter n.