Disruption of SRC function may impair vascular remodeling,[37] lead to endothelial dysfunction,[38] promote atherosclerosis,[39] and exacerbate reperfusion injury.[40] Although there is currently no in vivo evidence showing that aspartame directly alters SRC expression, its predicted binding capacity and the pivotal role of SRC in vascular stability underscore the need to explore aspartame’s potential interference with SRC-mediated signaling. The gene discussed is SRC; the disease is endothelial dysfunction.