NPM1 and acute myeloid leukemia: Other frequently observed abnormalities include inv(16), 11q23, t(9;11), t(1;11), deletions in chromosomes 4, 7, 11, 5q−, 16q, and 20.[16] Commonly mutated genes in MS include DNMT3A, FLT3, NPM1, C-Kit, and CEBPA, which are also commonly associated with AML.[17]