Although some scholars consider that IGFBP-2 acts as a negative regulator of IGFs in bone formation by inhibiting osteoblast proliferation and differentiation, and collagen synthesis,[8–10] there is evidence suggesting that IGFBP-2 promotes skeletal metabolism and prevents bone loss.[11,21,22] In this regard, the present study showed a negative correlation between IGFBP-2 and osteoporosis, indicating that it has a preventive effect on the development of osteoporosis, a finding consistent with previous observational studies. The gene discussed is IGFBP2; the disease is osteoporosis.