The strengths lie primarily in the design of the MR study, which effectively reduced bias from confounding factors and reversed causality that can be present in observational studies.[37] The study was also based on large-scale datasets that were used to analyze the causal relationship between IGFBP 1-7 and osteoporosis that significantly enhanced the persuasiveness of our conclusions. This evidence concerns the gene IGFBP1 and osteoporosis.