IGFBP2 and osteoporosis: Based on the IVW results, we identified a causal relationship between IGFBP-2 and osteoporosis, in which IGFBP-2 prevented the development of osteoporosis (IVW, P = .006; odds ratio = 0.998; β = −0.0022; 95% confidence interval: 0.996–0.999).