Previous research has shown that aside from IGFBP-2, IGFBP-3, -4, and -5 also exhibit a dual role that includes both positive and negative aspects under the influence of various factors.[8,9] IGFBP-1 and -6 are generally considered to have inhibitory effects, while IGFBP-7 prevents osteoporosis by reducing bone loss.[6,10] However, the current study showed no significant causal relationship between osteoporosis and IGFBP-1 or IGFBP-3 to -7, a finding which differs somewhat from many published observational studies. This evidence concerns the gene IGFBP3 and osteoporosis.