However, the present study did not show a significant causal relationship between the remaining 6 IGFBPs and osteoporosis (P > .05), including IGFBP-1 (IVW, P = .129; OR = 0.999; β = −0.0012; 95% CI, 0.997–1.000), IGFBP-3 (IVW, P = .758; OR = 1.000; β = −0.0002; 95% CI, 0.998–1.001), IGFBP-4 (WR, P = .474; OR = 1.001; β = 0.0009; 95% CI, 0.998–1.003), IGFBP-5 (IVW, P = .695; OR = 1.000; β = 0.0004; 95% CI, 0.999–1.002), IGFBP-6 (IVW, P = .135; OR = 0.998; β = −0.0017; 95% CI, 0.996–1.001), IGFBP-7 (IVW, P = .408; OR = 0.999; β = −0.0011; 95% CI, 0.996–1.002). Here, IGFBP4 is linked to osteoporosis.