However, in a cross-sectional study of 85 postmenopausal women, Shi et al[36] examined the relationship between IGFBP-3 and bone mineral density at the lumbar spine and femoral neck and found that IGFBP-3 levels were significantly higher in the osteoporosis group than in the normal group, with IGFBP-3 inversely correlated with bone mineral density. Here, IGFBP3 is linked to osteoporosis.