The PI3K/AKT/HIF-1α signaling pathway is closely related to the occurrence and development of tumors, and inhibiting this pathway can suppress cancer cell proliferation and promote apoptosis.[44] In our study, 3 active components all had varying degrees of downregulating effects on ERBB2 expression, with the QUE group showing significant downregulation. The gene discussed is HIF1A; the disease is cancer.