KEGG pathways associated with RCC include AGE-RAGE signaling pathway in diabetic complications, Proteoglycans in cancer, HIF-1 signaling pathway, etc. Among them, AGE-RAGE signaling pathway in diabetic complications involves 9 hub targets, including 7 upregulated genes (VEGFA, IL1B, ICAM1, VCAM1, TGFB1, SERPINE1, CCND1, EDN1) and 1 downregulated gene (PRKCA). This evidence concerns the gene ICAM1 and cancer.