IL6 and Hypoalbuminemia: These mediators – such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) – not only contribute to immune system dysregulation but also suppress hepatic albumin synthesis, directly resulting in hypoalbuminemia.[16,17] Hypoalbuminemia itself is strongly linked to impaired immune function and poor clinical outcomes in septic patients.